LSZ102 - From MedChem to manufacturing process
题??目：LSZ102 - From MedChem to manufacturing process
报告人：Dr. Michael Parmentier
????????Chemical & Analytical Development,?
????????Novartis Pharma AG,Basel,Switzerland
主持人：马大为 院士
时 ?间：2025年9月23日（星期二）下午 14:30 - 16:00
地 ?点：君谋楼二楼 第一会议室
欢迎听讲！
【Abstract】
The process development for the selective estrogen receptor degrader (SERD) candidate LSZ102 is outlined, emphasizing the transition from medicinal chemistry synthesis to large-scale production. The synthesis was significantly enhanced by revising the initial disconnection strategy, which led to improvements in overall yield, the elimination of chromatographic purifications, and a reduction in the number of steps. Additionally, an alternative micellar chemistry process for the crucial C-H functionalization step is introduced, which notably decreases a critical impurity level. Special consideration was given to the scalability of reaction conditions, environmental impact, and safety.
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